Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding.

Chen, Deliang; Li, Yibao; Li, Xun; Hong, Xuechuan; Fan, Xiaolin; Savidge, Tor

Chen, Deliang; Li, Yibao; Li, Xun; Hong, Xuechuan; Fan, Xiaolin; Savidge, Tor.

Afiliación

Chen D; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
Li Y; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
Li X; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
Hong X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and Hubei Province, Wuhan University School of Pharmaceutical Sciences Wuhan 430071 China.
Fan X; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
Savidge T; Department of Pathology & Immunology, Baylor College of Medicine Houston TX 77030 USA tor.savidge@bcm.edu.

Chem Sci ; 13(27): 8193-8202, 2022 Jul 13.

Article en En | MEDLINE | ID: mdl-35919436

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

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