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Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP.
Pal, Arindom; Gori, Sadakatali; Yoo, Seung-Wan; Thomas, Ajit G; Wu, Ying; Friedman, Jacob; Tenora, Lukás; Bhasin, Harshit; Alt, Jesse; Haughey, Norman; Slusher, Barbara S; Rais, Rana.
Afiliación
  • Pal A; Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Gori S; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Yoo SW; Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Thomas AG; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Wu Y; Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Friedman J; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Tenora L; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Bhasin H; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Alt J; Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Haughey N; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Slusher BS; Department of Neurology, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
  • Rais R; Johns Hopkins Drug Discovery, Johns Hopkins School of Medicine, Baltimore Maryland 21205, United States.
J Med Chem ; 65(16): 11111-11125, 2022 08 25.
Article en En | MEDLINE | ID: mdl-35930706
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos