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Case-fatality and sequelae following acute bacterial meningitis in South Africa, 2016 through 2020.
Meiring, Susan; Cohen, Cheryl; de Gouveia, Linda; Plessis, Mignon du; Quan, Vanessa; Kleynhans, Jackie; Menezes, Colin; Reubenson, Gary; Dawood, Halima; Nchabeleng, Maphoshane; Said, Mohamed; Mvelase, Nomonde; Mahabeer, Prasha; Chomba, Rispah; Lekalakala, Ruth; Nana, Trusha; Chibabhai, Vindana; Black, Marianne; von Gottberg, Anne.
Afiliación
  • Meiring S; Division of Public Health Surveillance and Response, National Institute for Communicable Diseases, Johannesburg, South Africa; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: susan.meiring@nhls.ac.za.
  • Cohen C; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa. Electronic address: cherylc@nicd.ac.za.
  • de Gouveia L; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa. Electronic address: lindad@nicd.ac.za.
  • Plessis MD; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: mignond@nicd.ac.za.
  • Quan V; Division of Public Health Surveillance and Response, National Institute for Communicable Diseases, Johannesburg, South Africa. Electronic address: vanessaq@nicd.ac.za.
  • Kleynhans J; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa. Electronic address: jackiel@nicd.ac.za.
  • Menezes C; Division of Infectious Diseases, Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa; School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: colin.menezes@wits.ac.za.
  • Reubenson G; Rahima Moosa Mother & Child Hospital, Department of Paediatrics & Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: gary.reubenson@wits.ac.za.
  • Dawood H; Department of Medicine, Pietermaritzburg Hospital Complex, Pietermaritzburg, South Africa; Caprisa, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. Electronic address: pmbiddoc@gmail.com.
  • Nchabeleng M; Medical Microbiology Laboratory, National Health Laboratory Service, Dr George Mukhari Tertiary Hospital, Garankuwa, South Africa; Microbiology Department, Sefako Makgatho Health Sciences University, Garankuwa, South Africa. Electronic address: maphoshane.nchabeleng@smu.ac.za.
  • Said M; Medical Microbiology Laboratory, National Health Laboratory Service, Tswane Academic Hospital, Pretoria, South Africa; Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa. Electronic address: Mohamed.said@nhls.ac.za.
  • Mvelase N; Medical Microbiology Laboratory, National Health Laboratory Service, KwaZulu-Natal Academic Complex, Durban, South Africa; School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. Electronic address: nomonde.dlamini@nhls.ac.za
  • Mahabeer P; Medical Microbiology Laboratory, National Health Laboratory Service, KwaZulu-Natal Academic Complex, Durban, South Africa; School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa. Electronic address: mahabeerp2@ukzn.ac.za.
  • Chomba R; Division of Clinical Microbiology and Infectious Diseases, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; Medical Microbiology Laboratory, National Health Laboratory Service, Helen Joseph Academic Hospital, Johannesburg, South Africa. Electronic address: rispah.cho
  • Lekalakala R; Division of Medical Microbiology, Department of Pathology, University of Limpopo, Polokwane, South Africa; Medical Microbiology Laboratory, National Health Laboratory Service, Polokwane Academic Hospital, Polokwane, South Africa. Electronic address: mlekalakala@nhls.ac.za.
  • Nana T; Division of Clinical Microbiology and Infectious Diseases, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; Medical Microbiology Laboratory, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. Electronic ad
  • Chibabhai V; Division of Clinical Microbiology and Infectious Diseases, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; Medical Microbiology Laboratory, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. Electronic ad
  • Black M; Division of Clinical Microbiology and Infectious Diseases, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa; Medical Microbiology Laboratory, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa. Electronic ad
  • von Gottberg A; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: annev@nicd.ac.za.
Int J Infect Dis ; 122: 1056-1066, 2022 Sep.
Article en En | MEDLINE | ID: mdl-35934172
OBJECTIVES: Providing country-specific estimates of case fatality and sequelae from bacterial meningitis (BM) is important to evaluate and monitor progress toward the World Health Organization's roadmap to "defeating meningitis by 2030". METHODS: From 2016-2020, GERMS-SA conducted enhanced surveillance at 26 hospitals across South Africa. Episodes of laboratory-confirmed BM due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis were included. Risk factors for in-hospital death and sequelae at hospital discharge among survivors were analyzed. RESULTS: Of 12,717 invasive bacterial infections reported nationally, 39% (4980) were from enhanced surveillance sites, including 4159 pneumococcal, 640 H. influenzae, and 181 meningococcal infections. BM accounted for 32% (1319/4159) of pneumococcal, 21% (136/640) of H. influenzae, and 83% (151/181) of meningococcal invasive diseases. Clinical data were available for 91% (1455/1606) of BM: 26% (376/1455) were aged <5 years, 50% (726/1455) were female, and 62% (723/1171) with known HIV results, were HIV-infected. In-hospital case fatality was 37% (534/1455), and 24% (222/921) of survivors had adverse sequelae. Risk factors for death included altered mental status, HIV infection, and comorbidities. Risk factors for adverse sequelae included altered mental status and antimicrobial nonsusceptibility. CONCLUSION: BM in South Africa has a high case fatality, and adverse sequelae frequently occur among survivors. Those with comorbidities (including HIV) are at the highest risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Meningitis Bacterianas / Meningitis Meningocócica / Meningitis Neumocócica / Neisseria meningitidis Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article Pais de publicación: Canadá

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Meningitis Bacterianas / Meningitis Meningocócica / Meningitis Neumocócica / Neisseria meningitidis Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article Pais de publicación: Canadá