Application of Data Science to Quantify the Effect of Propofol Infusion on Postoperative Nausea and Vomiting.
AANA J
; 90(4): 263-270, 2022 Aug.
Article
en En
| MEDLINE
| ID: mdl-35943751
ABSTRACT
The effectiveness of propofol infusion on postoperative nausea and vomiting (PONV) is poorly understood in relation to various patient and procedure characteristics. This retrospective cohort study aimed to quantify the effectiveness of propofol infusion when administered either via total intravenous administration (TIVA) or combined intravenous anesthesia (CIVA) with inhalational agents on PONV. The relationship between propofol infusion and PONV was characterized controlling for patient demographics, procedure characteristics, PONV risk factors, and antiemetic drugs in adult patients (age ≥18 years) undergoing general anesthesia. Learned coefficients from multivariate regression models were reported as "lift" which represents the percentage change in the base likelihood of observing PONV if a variable is present versus absent. In a total of 41,490 patients, models showed that propofol infusion has a naive effect on PONV with a lift of -41% (P < .001) when using TIVA and -17% (P < .001) when using CIVA. Adding interaction terms to the model resulted in the loss of statistical significance in these relationships (lift of -30%, P = .23, when using TIVA, and -42%, P = .36, when using CIVA). It was further found that CIVA/TIVA are ineffective in short cases (CIVA * short surgery duration lift = 49%, P < .001 and TIVA * short surgery duration lift = 56%, P < .001).
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propofol
/
Náusea y Vómito Posoperatorios
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Humans
Idioma:
En
Revista:
AANA J
Año:
2022
Tipo del documento:
Article