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Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).
Cieuta-Walti, Cécile; Cuenca-Royo, Aida; Langohr, Klaus; Rakic, Claire; López-Vílchez, Ma Ángeles; Lirio, Julián; González-Lamuño Leguina, Domingo; González, Teresa Bermejo; García, Jordi García; Roure, Maria Rimblas; Aldea-Perona, Ana; Forcano, Laura; Gomis-Gonzalez, Maria; Cés, Sebastià Videla; Lacaille, Florence; Ravel, Aimé; Mircher, Clotilde; Walti, Hervé; Janel, Nathalie; Dairou, Julien; Lévy, Marilyne; Durand, Sophie; Dierssen, Mara; Sacco, Silvia; Fornell, Rafael de la Torre.
Afiliación
  • Cieuta-Walti C; Institut Jérôme Lejeune, Paris, France; Sherbrooke University, Québec, Canada.
  • Cuenca-Royo A; Integrative Pharmacology and Systems Neuroscience research group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Langohr K; Integrative Pharmacology and Systems Neuroscience research group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain; Department of Statistics and Operations Research, Universitat Politècnica de Catalunya/BarcelonaTECH, Barcelona, Spain.
  • Rakic C; Institut Jérôme Lejeune, Paris, France.
  • López-Vílchez MÁ; Pediatric Sevice, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Lirio J; Social Pediatrics Division, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
  • González-Lamuño Leguina D; Division of Pediatrics, Hospital Universitario Marqués de Valdecilla - Universidad de Cantabria - Instituto de Investigación Valdecilla (IDIVAL), Santander, Cantabria, Spain.
  • González TB; Instituto Hispalense de Pediatría, Sevilla, Spain.
  • García JG; Pediatric Sevice, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Roure MR; Division of Pediatrics, Hospital Universitari Sant Joan de Reus, Tarragona, Spain.
  • Aldea-Perona A; Clinical Research Unit, IMIM- Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Forcano L; Integrative Pharmacology and Systems Neuroscience research group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Gomis-Gonzalez M; Integrative Pharmacology and Systems Neuroscience research group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.
  • Cés SV; Clinical Research Support Unit [HUB·IDIBELL], Clinical Pharmacology Department, Bellvitge University Hospital, Barcelona, Spain; Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, IDIBELL, University of Barcelona, Barcelona, Spain.
  • Lacaille F; Service de Gastro-entérologie-Hépatologie-Nutrition Pédiatriques, Hôpital Necker-Enfants Malades Paris, Paris, France.
  • Ravel A; Institut Jérôme Lejeune, Paris, France.
  • Mircher C; Institut Jérôme Lejeune, Paris, France.
  • Walti H; Institut Jérôme Lejeune, Paris, France.
  • Janel N; Unité de Biologie Fonctionnelle et Adaptative (BFA), Laboratoire Processus dégénératifs, Stress et Vieillissement, UMR 8251, CNRS, Université de Paris, Paris, France.
  • Dairou J; UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université de Paris, Paris, France.
  • Lévy M; Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C-Necker, Hôpital Universitaire Necker-Enfants Malades, APHP, Université de Paris, Paris, France.
  • Durand S; Institut Jérôme Lejeune, Paris, France.
  • Dierssen M; Cellular & Systems Neurobiology, Systems Biology Program. Center for Genomic Regulation, Barcelona, Spain.
  • Sacco S; Institut Jérôme Lejeune, Paris, France.
  • Fornell RT; Sherbrooke University, Québec, Canada; Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: rtorre@imim.es.
Genet Med ; 24(10): 2004-2013, 2022 10.
Article en En | MEDLINE | ID: mdl-35951014
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catequina / Síndrome de Down Tipo de estudio: Clinical_trials Límite: Child / Female / Humans / Male Idioma: En Revista: Genet Med Asunto de la revista: GENETICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catequina / Síndrome de Down Tipo de estudio: Clinical_trials Límite: Child / Female / Humans / Male Idioma: En Revista: Genet Med Asunto de la revista: GENETICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos