Oxidative degradation in pharmaceuticals: Mechanism and stabilization of a spray-dried amorphous drug - A case study.

Kotha, Raghavendhar R; Zhang, Kelly; Yehl, Peter; Kumar, Archana

Kotha, Raghavendhar R; Zhang, Kelly; Yehl, Peter; Kumar, Archana.

Afiliación

Kotha RR; Department of Small Molecule Analytical Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Zhang K; Department of Small Molecule Analytical Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Yehl P; Department of Small Molecule Analytical Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Kumar A; Department of Small Molecule Analytical Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: archanakgupta@gmail.com.

J Pharm Biomed Anal ; 220: 114962, 2022 Oct 25.

Article en En | MEDLINE | ID: mdl-35963017

Asunto(s)

Excipientes; Galato de Propilo; Quelantes; Composición de Medicamentos/métodos; Estabilidad de Medicamentos; Ácido Edético; Excipientes/química; Derivados de la Hipromelosa/química; Estrés Oxidativo; Polímeros/química; Succinatos

Palabras clave

Antioxidants; Drug stability; Forced degradation; Oxidative degradation; Pharmaceuticals; Spray-dried formulations

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Galato de Propilo / Excipientes Idioma: En Revista: J Pharm Biomed Anal Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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