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Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe.
Ha, Byunghang; Liang, Kaitlyn; Liu, Cheng; Melemenidis, Stavros; Manjappa, Rakesh; Viswanathan, Vignesh; Das, Neeladrisingha; Ashraf, Ramish; Lau, Brianna; Soto, Luis; Graves, Edward E; Rao, Jianghong; Loo, Billy W; Pratx, Guillem.
Afiliación
  • Ha B; Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Liang K; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
  • Liu C; Molecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, Stanford, CA 94305, USA.
  • Melemenidis S; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Manjappa R; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Viswanathan V; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Das N; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Ashraf R; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Lau B; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Soto L; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Graves EE; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Rao J; Molecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, Stanford, CA 94305, USA.
  • Loo BW; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
  • Pratx G; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA. Electronic address: pratx@stanford.edu.
Radiother Oncol ; 176: 239-243, 2022 11.
Article en En | MEDLINE | ID: mdl-35964762
ABSTRACT
The rapid depletion of oxygen during irradiation at ultra-high dose rate calls for tissue oximeters capable of high temporal resolution. This study demonstrates a water-soluble phosphorescent nanoprobe and fiber-coupled instrument, which together are used to measure the kinetics of oxygen depletion at 200 Hz during irradiation of in vitro solutions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Oximetría Límite: Humans Idioma: En Revista: Radiother Oncol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Oximetría Límite: Humans Idioma: En Revista: Radiother Oncol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos