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The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation.
Cianflone, Eleonora; Scalise, Mariangela; Marino, Fabiola; Salerno, Luca; Salerno, Nadia; Urbanek, Konrad; Torella, Daniele.
Afiliación
  • Cianflone E; Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
  • Scalise M; Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
  • Marino F; Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
  • Salerno L; Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
  • Salerno N; Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
  • Urbanek K; Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
  • Torella D; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80138 Naples, Italy.
Clin Sci (Lond) ; 136(16): 1179-1203, 2022 08 31.
Article en En | MEDLINE | ID: mdl-35979890
ABSTRACT
Cardiac muscle damage-induced loss of cardiomyocytes (CMs) and dysfunction of the remaining ones leads to heart failure, which nowadays is the number one killer worldwide. Therapies fostering effective cardiac regeneration are the holy grail of cardiovascular research to stop the heart failure epidemic. The main goal of most myocardial regeneration protocols is the generation of new functional CMs through the differentiation of endogenous or exogenous cardiomyogenic cells. Understanding the cellular and molecular basis of cardiomyocyte commitment, specification, differentiation and maturation is needed to devise innovative approaches to replace the CMs lost after injury in the adult heart. The transcriptional regulation of CM differentiation is a highly conserved process that require sequential activation and/or repression of different genetic programs. Therefore, CM differentiation and specification have been depicted as a step-wise specific chemical and mechanical stimuli inducing complete myogenic commitment and cell-cycle exit. Yet, the demonstration that some microRNAs are sufficient to direct ESC differentiation into CMs and that four specific miRNAs reprogram fibroblasts into CMs show that CM differentiation must also involve negative regulatory instructions. Here, we review the mechanisms of CM differentiation during development and from regenerative stem cells with a focus on the involvement of microRNAs in the process, putting in perspective their negative gene regulation as a main modifier of effective CM regeneration in the adult heart.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Insuficiencia Cardíaca Tipo de estudio: Guideline Límite: Adult / Humans Idioma: En Revista: Clin Sci (Lond) Año: 2022 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Insuficiencia Cardíaca Tipo de estudio: Guideline Límite: Adult / Humans Idioma: En Revista: Clin Sci (Lond) Año: 2022 Tipo del documento: Article País de afiliación: Italia