Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity.

Wang, Xueyao; Hu, Rui; Song, Zhenwei; Zhao, Huajun; Pan, Zhaoyi; Feng, Yujie; Yu, Yating; Han, Qiuju; Zhang, Jian

Wang, Xueyao; Hu, Rui; Song, Zhenwei; Zhao, Huajun; Pan, Zhaoyi; Feng, Yujie; Yu, Yating; Han, Qiuju; Zhang, Jian.

Afiliación

Wang X; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Hu R; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Song Z; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Zhao H; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Pan Z; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Feng Y; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Yu Y; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Han Q; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Zhang J; Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China. Electronic address: zhangj65@sdu.edu.cn.

Cancer Lett ; 547: 215880, 2022 Oct 28.

Article en En | MEDLINE | ID: mdl-35981569

Asunto(s)

Carcinoma Hepatocelular; Estrés del Retículo Endoplásmico; Neoplasias Hepáticas; Apoptosis; Carcinoma Hepatocelular/tratamiento farmacológico; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Línea Celular Tumoral; Humanos; Neoplasias Hepáticas/tratamiento farmacológico; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Nucleotidiltransferasas/genética; Nucleotidiltransferasas/metabolismo; Nucleotidiltransferasas/uso terapéutico; Factor de Transcripción STAT3/genética; Factor de Transcripción STAT3/metabolismo; Sorafenib/farmacología; Sorafenib/uso terapéutico; Microambiente Tumoral

Palabras clave

CD103(+) DCs; ER stress; PKR; STING; cGAS; p-eIF2α

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Estrés del Retículo Endoplásmico / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Cancer Lett Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda

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