Control of the Biodegradability of Piezoelectric Peptide Nanotubes Integrated with Hydrophobic Porphyrin.
ACS Appl Mater Interfaces
; 14(34): 38778-38785, 2022 Aug 31.
Article
en En
| MEDLINE
| ID: mdl-35983899
ABSTRACT
Diphenylalanine (FF) is a piezoelectric material that is widely known for its high piezoelectric constant, self-assembly characteristics, and ease of manufacture. Because of its biocompatible nature, it is useful for implantable applications. However, its use in real applications is challenging because it degrades too easily in the body due to its solubility in water (0.76 g/mL). Upon incorporation of hydrophobic and biocompatible porphyrins into the FF, the degradability of the piezoelectric FF and their piezoelectric nanogenerators (PENGs) is controlled. Porphyrin-incorporated FFs are also formed as piezoelectric nanostructures well aligned on the substrate through self-assembly, and their piezoelectric properties are comparable to those of FF. The FF-based PENG degrades in only 5 min, whereas the FF-porphyrin-based PENG produces a stable output for >15 min in phosphate-buffered saline. This strategy for realizing biodegradable functional materials and devices with tunable degradation rates in the body can be applied to many implantable electronics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Porfirinas
/
Nanotubos de Péptidos
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Asunto de la revista:
BIOTECNOLOGIA
/
ENGENHARIA BIOMEDICA
Año:
2022
Tipo del documento:
Article