Hippocampal intracerebral evoked potentials as a marker of its functionality in drug-resistant epilepsy.
Neurophysiol Clin
; 52(4): 323-332, 2022 Aug.
Article
en En
| MEDLINE
| ID: mdl-35989149
ABSTRACT
OBJECTIVES:
To assess hippocampal function during stereoelectroencephalography (SEEG) investigations through the study of the medial temporal lobe event-related potential (ERP) MTL-P300.METHODS:
We recorded the MTL-P300 during a visual oddball task, using hippocampal electrodes implanted for SEEG in 71 patients, in a preoperative epilepsy investigation. The presence of an MTL-P300 and its amplitude were correlated with hippocampal involvement during seizures and memory function.RESULTS:
Analysis using ROC curves revealed that an MTL-P300 amplitude below -46 µV, has a specificity of 93.3% in detecting the epileptogenic zone, and absence of the MTL-P300 in the left hippocampus of patients with typical language organization was associated with marked alteration of verbal memory scores. There was a significant correlation between performance in non-verbal memory tests and the amplitude of the MTL-P300 in the right hippocampus of patients with left hemispheric seizures (immediate visual recall r = 0.67, p = 0.005; delayed visual recall r = 0.56, p = 0.025). Using a linear regression, we confirmed that the absence of the MTL-P300 in the left hippocampus, the involvement of the left hippocampus during seizures, and the duration of epilepsy were predictors of verbal memory deficits.CONCLUSION:
Analysis of the MTL-P300 during SEEG recording provides relevant information for the analysis of hippocampal functionality and can help to localize the epileptogenic zone.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epilepsia
/
Epilepsia del Lóbulo Temporal
/
Epilepsia Refractaria
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Neurophysiol Clin
Asunto de la revista:
FISIOLOGIA
/
NEUROLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Brasil