Outcome of adolescents and young adults with acute lymphoblastic leukemia in a single center in Brazil.
Hematol Transfus Cell Ther
; 45 Suppl 2: S108-S112, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-35989249
ABSTRACT
INTRODUCTION:
Acute lymphoblastic leukemia (ALL) presents a poor prognosis in adults. The adoption of pediatric protocols has been changing this scenario, especially for adolescents and young adults (AYA). OBJECTIVE ANDMETHOD:
We aimed to evaluate a consecutive series of patients treated at the State Institute of Hematology of Rio de Janeiro between 2012 and 2020, focusing on the AYA subgroup.RESULT:
The B-ALL was the most frequent subtype (81.6%) and AYA, the predominant age group (57.7%). The median overall survival (OS) was 9.4 months. High early mortality was observed and sepsis was the main cause of death. Better OS results were noted in AYA, in comparison to over 39y (13.3 × 6.2 months, respectively), the Berlin-Frankfurt-Münster (BFM) being the protocol of choice in this group.CONCLUSION:
The use of the pediatric protocol seems to improve the OS of AYA, however, high rates of deaths from infection were observed, demonstrating the need for advances in the Brazilian public system clinical support.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Guideline
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Hematol Transfus Cell Ther
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil