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Multiple-ascending doses of ACT-1014-6470, an oral complement factor 5a receptor 1 (C5a1 receptor) antagonist: Tolerability, pharmacokinetics and target engagement.
Anliker-Ort, Marion; Dingemanse, Jasper; Farine, Hervé; Groenen, Peter; Kornberger, Rüdiger; van den Anker, John; Kaufmann, Priska.
Afiliación
  • Anliker-Ort M; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
  • Dingemanse J; Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
  • Farine H; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
  • Groenen P; Translational Biomarkers, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
  • Kornberger R; Translational Biomarkers, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
  • van den Anker J; Parexel International GmbH, Berlin, Germany.
  • Kaufmann P; Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Br J Clin Pharmacol ; 89(1): 380-389, 2023 01.
Article en En | MEDLINE | ID: mdl-36000981
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor Va / Metaloproteinasa 9 de la Matriz Tipo de estudio: Clinical_trials Límite: Female / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor Va / Metaloproteinasa 9 de la Matriz Tipo de estudio: Clinical_trials Límite: Female / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Año: 2023 Tipo del documento: Article País de afiliación: Suiza