Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8<sup>+</sup> T cells and the exclusion of Treg cells.

Wang, Rui; Liu, Hongchuan; He, Peng; An, Duopeng; Guo, Xiaohan; Zhang, Xuyao; Feng, Meiqing

Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8⁺ T cells and the exclusion of Treg cells.

Wang, Rui; Liu, Hongchuan; He, Peng; An, Duopeng; Guo, Xiaohan; Zhang, Xuyao; Feng, Meiqing.

Afiliación

Wang R; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
Liu H; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
He P; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
An D; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
Guo X; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
Zhang X; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
Feng M; Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.

Front Immunol ; 13: 947756, 2022.

Article en En | MEDLINE | ID: mdl-36003387

Asunto(s)

Linfocitos T CD8-positivos; Neoplasias Colorrectales; Humanos; Inhibidores de Puntos de Control Inmunológico/farmacología; Inhibidores de Puntos de Control Inmunológico/uso terapéutico; Inmunoterapia; Inhibidores de PCSK9; Proproteína Convertasa 9/metabolismo; Linfocitos T Reguladores

Palabras clave

CD8+ T cells; PCSK9; PD-1; regulatory T cells; tumor microenvironment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Linfocitos T CD8-positivos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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