Role of gut microbiota in depression: Understanding molecular pathways, recent research, and future direction.
Behav Brain Res
; 436: 114081, 2023 01 05.
Article
en En
| MEDLINE
| ID: mdl-36037843
ABSTRACT
Gut microbiota, also known as the "second brain" in humans because of the regulatory role it has on the central nervous system via neuronal, chemical and immune pathways. It has been proven that there exists a bidirectional communication between the gut and the brain. Increasing evidence supports that this crosstalk is linked to the etiology and treatment of depression. Reports suggest that the gut microbiota control the host epigenetic machinery in depression and gut dysbiosis causes negative epigenetic modifications via mechanisms like histone acetylation, DNA methylation and non-coding RNA mediated gene inhibition. The gut microbiome can be a promising approach for the management of depression. The diet and dietary metabolites like kynurenine, tryptophan, and propionic acid also greatly influence the microbiome composition and thereby, the physiological activities. This review gives a bird-eye view on the pathological updates and currently used treatment approaches targeting the gut microbiota in depression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Probióticos
/
Microbioma Gastrointestinal
Límite:
Humans
Idioma:
En
Revista:
Behav Brain Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
India