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Role of 5-HT2A Receptor in Modulating Glutamatergic Activity in the Ventrolateral Orbital Cortex: Implication in Trigeminal Neuralgia.
Yuan, Shanshan; Wang, Na; Yao, Yunxia; Liu, Junhong; Gao, Mingwei; Mo, Hongbing; Zhang, Shuzhuo; Su, Ruibin.
Afiliación
  • Yuan S; Beijing Institute of Pharmacology and Toxicology, Beijing, China; School of Stomatology, Jiamusi University, Jiamusi, China.
  • Wang N; Beijing Institute of Pharmacology and Toxicology, Beijing, China.
  • Yao Y; Beijing Institute of Pharmacology and Toxicology, Beijing, China.
  • Liu J; Beijing Institute of Pharmacology and Toxicology, Beijing, China.
  • Gao M; Beijing Institute of Pharmacology and Toxicology, Beijing, China.
  • Mo H; School of Stomatology, Jiamusi University, Jiamusi, China.
  • Zhang S; Beijing Institute of Pharmacology and Toxicology, Beijing, China. Electronic address: Zhangshuzhuo9@hotmail.com.
  • Su R; Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Neuroscience ; 502: 107-116, 2022 Oct 15.
Article en En | MEDLINE | ID: mdl-36038038
5-HT2A receptors (5-HT2ARs) are widely expressed in the central nervous system, including in the ventrolateral orbital cortex (VLO). The VLO is an important cortical component for pain processing. Brain 5-HT2ARs are implicated in both pro- and anti- nociceptive functions. However, the roles of 5-HT2ARs in the VLO in trigeminal neuralgia and neuronal synaptic function remain to be understood. We used chronic constriction injury of infraorbital nerve (IoN-CCI) model and shRNA mediated gene knockdown in mice to investigate the role of 5-HT2ARs in the VLO in trigeminal neuralgia. We found that knockdown of 5-HT2ARs in the VLO aggravated spontaneous pain and mechanical allodynia in mice after IoN-CCI. At the synaptic level, decreasing 5-HT2AR expression by shRNA or inhibition of 5-HT2AR activity by its antagonist ketanserin decreased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) of the neurons in the VLO, whereas 5-HT2AR partial agonist 2,5-Dimethoxy-4-iodoamphetamine (DOI) enhanced sEPSCs of the neurons in the VLO. In summary, 5-HT2ARs in the VLO modulate the trigeminal pain by regulating neuronal glutamatergic activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuralgia del Trigémino Límite: Animals Idioma: En Revista: Neuroscience Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuralgia del Trigémino Límite: Animals Idioma: En Revista: Neuroscience Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos