Your browser doesn't support javascript.
loading
Carbon Nanostructures for Ocular Tissue Reinforcement.
Silvestre, Joaquin; Chen, Shihao; Zheng, Zheng; Vega, Alfredo; Chen, Tong; Rodríguez-Reinoso, Francisco; Zhu, Pin; Zeng, Shuang; Zheng, Yaru; Bao, Fangjun; Liu, Yong; Alió, Jorge L.
Afiliación
  • Silvestre J; Laboratorio de Materiales Avanzados, Departamento de Química Inorgánica-IUMA, Universidad de Alicante, Spain.
  • Chen S; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zheng Z; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Vega A; Research and Development Department, VISSUM Corp., Alicante, Spain.
  • Chen T; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Rodríguez-Reinoso F; Laboratorio de Materiales Avanzados, Departamento de Química Inorgánica-IUMA, Universidad de Alicante, Spain.
  • Zhu P; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zeng S; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zheng Y; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Bao F; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Liu Y; Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Alió JL; Research and Development Department, VISSUM Corp., Alicante, Spain.
Transl Vis Sci Technol ; 11(9): 1, 2022 09 01.
Article en En | MEDLINE | ID: mdl-36048013
ABSTRACT

Purpose:

The purpose of this study was to improve the biomechanical properties of the cornea through the incorporation of carbon nanostructures.

Methods:

Healthy Japanese rabbits were used to evaluate the effect of carbon nanostructures' incorporation in the cornea. Rabbits were divided in two groups A and B. In each of these groups, the corneas were divided in (i) corneas not submitted to any treatment (the control group), (ii) corneas modified either with carbon nanostructures (group A), or with the traditional cross-linking technology (group B). After modification, rabbits were euthanized at different time intervals. The biomechanical properties of the treated corneas were evaluated using the inflation method.

Results:

Biomechanical tests based on the inflation method show that the incorporation of carbon nanostructures to the cornea and their proper distribution within it gives rise to a large improvement in the mechanical properties and tangential elastic modulus (up to 155%). These results anticipate that this novel and easy approach based on nanotechnology is able to compete with the actual cross-linking technology applied in clinical ophthalmology using a photosensitive molecule, such as riboflavin and unpleasant UV-A radiation.

Conclusions:

The incorporation of carbon nanostructures (single-walled carbon nanotubes and graphene) in corneal stroma is proposed as a promising alternative to improve the mechanical properties in the treated eyes. The proper dispersion of the carbon nanostructures a few days after implementation (down to 60 micrometers depth) explains the successful results achieved. Translational Relevance Nanotechnology applied to the eye constitutes a promising approach for ocular tissue reinforcement.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanotubos de Carbono / Nanoestructuras Límite: Animals Idioma: En Revista: Transl Vis Sci Technol Año: 2022 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanotubos de Carbono / Nanoestructuras Límite: Animals Idioma: En Revista: Transl Vis Sci Technol Año: 2022 Tipo del documento: Article País de afiliación: España