Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress.

Chen, Yihong; Shen, Junyan; Nilsson, Anna Hultgårdh; Goncalves, Isabel; Edsfeldt, Andreas; Engström, Gunnar; Zaigham, Suneela; Melander, Olle; Orho-Melander, Marju; Rauch, Uwe; Venuraju, Shreenidhi M; Lahiri, Avijit; Liang, Chun; Nilsson, Jan

Chen, Yihong; Shen, Junyan; Nilsson, Anna Hultgårdh; Goncalves, Isabel; Edsfeldt, Andreas; Engström, Gunnar; Zaigham, Suneela; Melander, Olle; Orho-Melander, Marju; Rauch, Uwe; Venuraju, Shreenidhi M; Lahiri, Avijit; Liang, Chun; Nilsson, Jan.

Afiliación

Chen Y; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Shen J; Department of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Nilsson AH; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Goncalves I; Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Edsfeldt A; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Engström G; Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Zaigham S; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Melander O; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Orho-Melander M; Department of Cardiology, Skåne University Hospital, Scania, Sweden.
Rauch U; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
Venuraju SM; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Lahiri A; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Liang C; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Nilsson J; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.

JACC Basic Transl Sci ; 7(8): 747-762, 2022 Aug.

Article en En | MEDLINE | ID: mdl-36061342

ABSTRACT

ABSTRACT

Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.

Palabras clave

AU, arbitrary unit; BrdU, bromodeoxyuridine; CVD, cardiovascular disease; EC, endothelial cell; HCASMC, human coronary artery smooth muscle cell; HDL, high-density lipoprotein; HGF, hepatocyte growth factor; HUVEC, human umbilical cord endothelial cell; ICD-9, International Classification of Diseases-9th Revision; IL, interleukin; LDL, low-density lipoprotein; MMP, matrix metalloproteinase; PlGF, placental growth factor; SMC, smooth muscle cell; TGF, transforming growth factor; TNF, tumor necrosis factor; TRAIL, tumor necrosis factorrelated apoptosis-inducing ligand; VEGF, vascular endothelial growth factor; apoptosis; atherosclerosis; endothelial cells; growth factors; injury; mRNA, messenger RNA; myocardial infarction; s, soluble; si-HGF, hepatocyte growth factor small interfering RNA; siRNA, small interfering RNA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Suecia

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