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Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents.
Wood, Tobias C; Cash, Diana; MacNicol, Eilidh; Simmons, Camilla; Kim, Eugene; Lythgoe, David J; Zelaya, Fernando; Turkheimer, Federico.
Afiliación
  • Wood TC; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • Cash D; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • MacNicol E; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • Simmons C; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • Kim E; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • Lythgoe DJ; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • Zelaya F; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
  • Turkheimer F; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, UK.
Wellcome Open Res ; 6: 109, 2021.
Article en En | MEDLINE | ID: mdl-36081865
ABSTRACT
Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO 2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Wellcome Open Res Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Wellcome Open Res Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM