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Generation of a gene-corrected human iPSC line (CSUASOi004-A-1) from a retinitis pigmentosa patient with heterozygous c.2699 G>A mutation in the PRPF6 gene.
Liang, Yuqin; Sun, Xihao; Duan, Chunwen; Zhou, Yalan; Cui, Zekai; Ding, Chengcheng; Gu, Jianing; Mao, Shengru; Ji, Shangli; Chan, Hon Fai; Tang, Shibo; Chen, Jiansu.
Afiliación
  • Liang Y; Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Sun X; Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Duan C; Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Zhou Y; Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Cui Z; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Ding C; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Gu J; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Mao S; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Ji S; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China.
  • Chan HF; Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, China.
  • Tang S; Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; CAS Center for Excellence in
  • Chen J; Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Aier Eye Institute, 18th Floor, The New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, China; Key Laboratory of Regenerati
Stem Cell Res ; 64: 102911, 2022 10.
Article en En | MEDLINE | ID: mdl-36103774
ABSTRACT
Retinitis pigmentosa (RP) is one of the most common inherited retinal diseases characterized by nyctalopia, progressive vision loss and visual field contraction. we previously generated an induced pluripotent stem cell line (CSUASOi004-A) from a RP patient with heterozygous PRPF6 c.2699 G>A (p.R900H) mutation. Here we corrected the PRPF6 c.2699 G>A mutation genetically using CRISPR/Cas9 technology to generate an isogenic control (CSUASOi004-A-1), which can provide a valuable resource in the research of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinitis Pigmentosa / Células Madre Pluripotentes Inducidas Límite: Humans Idioma: En Revista: Stem Cell Res Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinitis Pigmentosa / Células Madre Pluripotentes Inducidas Límite: Humans Idioma: En Revista: Stem Cell Res Año: 2022 Tipo del documento: Article País de afiliación: China