Gold nanoblackbodies mediated plasmonic photothermal cancer therapy for melanoma.
Nanomedicine (Lond)
; 17(19): 1323-1338, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-36136404
ABSTRACT
Aim:
Gold nanoblackbodies (AuNBs)-mediated plasmonic photothermal cancer therapy was investigated through melanoma-bearing mice. Materials &methods:
Polydopamine-coated Au nanoclusters were synthesized, termed AuNBs and PEGylated AuNBs (AuNBs-PEG). The photothermal response of AuNBs-PEG was evaluated upon low-intensity broadband near-infrared irradiation (785/62 nm; 0.9 Wcm-2), and cytotoxicity was assessed on B16-F10 cells. Further, the therapeutic potential of intravenously administered AuNBs-PEG was evaluated on B16-F10 melanoma in C57BL/6 mice.Results:
AuNBs-PEG showed an excellent photothermal response (photothermal conversion efficiency of 60.3%), robust photothermal stability and no cytotoxicity. For AuNB-mediated plasmonic photothermal therapy, an average temperature of 63°C was attained within 5 min of irradiation, and tumors were eradicated.Conclusion:
AuNBs-PEG are promising photothermal agents for treating melanoma through low-intensity broadband near-infrared irradiation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Melanoma Experimental
/
Oro
Límite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2022
Tipo del documento:
Article
País de afiliación:
India