Low intensity ultrasound enhances cisplatin uptake in vitro by cochlear hair cells.
JASA Express Lett
; 1(7): 072001, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-36154652
ABSTRACT
Drug delivery to the inner ear has been challenging due to the blood-labyrinth barrier. Intracochlear drug delivery is an invasive alternative with less pharmacokinetic variables. In this study, the effect of low intensity ultrasound on drug uptake by hair cells is investigated. Cochlear explants harvested from newborn mice were cultured in a medium containing cisplatin to emulate drug delivered to the endolymph. The results demonstrated the exposure to ultrasound stimulation effectively enhanced cisplatin uptake by hair cells. The uptake started from the apical side of the hair cells and progressed inward as the exposure time increased.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cisplatino
/
Oído Interno
Límite:
Animals
Idioma:
En
Revista:
JASA Express Lett
Año:
2021
Tipo del documento:
Article
País de afiliación:
Taiwán