Sex differences in the associations between psychological symptoms and tumor necrosis factor-alpha levels among obese and nonobese children aged 6-13 in Taiwan.
J Affect Disord
; 320: 241-246, 2023 01 01.
Article
en En
| MEDLINE
| ID: mdl-36162686
ABSTRACT
BACKGROUND:
Evidence of associations between psychological symptoms and tumor necrosis factor (TNF)-α level is scant, as is evidence on sex differences in associations for children and adolescents with obesity. This study examined sex differences in associations between psychological symptoms (self-concept, anxiety, depression, anger, and disruptive behavior) and TNF-α level in Taiwanese children and adolescents with healthy weight, overweight, or obesity.METHODS:
In 2010, 564 first, fourth, and seventh graders-comprising 250 children with overweight or obesity (44.3 %), 330 adolescents (58.5 %), and 303 males (53.7 %)-underwent a health examination and blood sampling and completed a questionnaire.RESULTS:
A significantly higher TNF-α level was found in children and adolescents with healthy weight than in those with overweight or obesity (median 14.5 vs. 4.1 (pg/mL); p < 0.001). In multiple linear regression models, anxiety was significantly positively associated with TNF-α level in female participants with healthy weight (ß = 0.11 per 10 increments in anxiety, 95 % confidence interval = 0.01-0.22).LIMITATIONS:
Given the cross-sectional nature of the study, no inferences of causal relationships among TNF-α level, obesity, and psychological symptoms could be made.CONCLUSIONS:
The findings enrich the literature on the TNF-α-psychological symptom association. Sex differences were found in children and adolescents without obesity rather than in those without obesity, and a higher TNF-α level was associated with increased anxiety in girls without obesity. The role of sex differences in the complex associations among psychological symptoms, TNF-α level, and overweight or obesity requires further investigation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Necrosis Tumoral alfa
/
Sobrepeso
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Affect Disord
Año:
2023
Tipo del documento:
Article
País de afiliación:
Taiwán