Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin / Wnt/ ß-catenin axis with subsequent inhibition of liver cancer stem cells.

Zakaria, Sherin; Allam, Shady; El-Sisi, Alaa E

Zakaria, Sherin; Allam, Shady; El-Sisi, Alaa E.

Afiliación

Zakaria S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kaferelsheikh University, 33516, Kaferelsheikh, Egypt.
Allam S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia University, 32511, Menoufia, Egypt.
El-Sisi AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, 31512, Tanta, Egypt.

Saudi Pharm J ; 30(8): 1170-1180, 2022 Aug.

Article en En | MEDLINE | ID: mdl-36164573

Palabras clave

ABC, ATP binding box; ACEI, Angiotensin converting enzyme inhibitors; ALDH1; ALDH1, Aldehyde dehydrogenases 1; ALT, Alanineaminotransferase; ANG II, Angiotensin II; APC, adenomatous polyposis coli protein; AST, Aspartate aminotransferase; DENA, Diethylnitrosamine; EpCAM, Epithelial cell adhesion molecule; GSK 3ß, glycogen synthase kinase-3ß; HCC, Hepatocellular carcinoma; LCSC, Liver cancer stem cells; Leptin; MMP-9, Metalloproteinase-9; PBS, Phosphate-buffered saline; PDGFR-ß, platelet-derived growth factor receptor; PRIN, Perindopril; Perindopril; SOR, Sorafenib; VEGF, Vascular endothelial growth factor; Wnt; mTOR, Mammalian target of rapamycin; ß-catenin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Saudi Pharm J Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación:

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