Epileptic Targets and Drugs: A Mini-Review.
Curr Drug Targets
; 24(3): 212-224, 2023.
Article
en En
| MEDLINE
| ID: mdl-36173074
ABSTRACT
BACKGROUND:
Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain.INTRODUCTION:
In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment.METHODS:
Several studies demonstrated the antiepileptic effect of drugs acting on the following targets N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver.RESULTS:
These studies highlight the importance of molecular docking.CONCLUSION:
Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epilepsia
Límite:
Humans
Idioma:
En
Revista:
Curr Drug Targets
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil