Brønsted acid catalyzed remote C6 functionalization of 2,3-disubstituted indoles with ß,γ-unsaturated α-ketoester.
Front Chem
; 10: 992398, 2022.
Article
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| MEDLINE
| ID: mdl-36176896
A metal-free catalytic approach for the remote C6-functionalization of 2,3-disubstituted indoles has been developed. In the presence of catalytic amounts of Brønsted acid, the ß,γ-unsaturated α-ketoesters react with 2,3-disubstituted indoles at the C6 position selectively. Under mild reaction conditions, a range of C6-functionalized indoles were prepared with good yields and excellent regioselectivity. This methodology provides a concise and efficient route for the synthesis of C6-functionalized indole derivatives.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Front Chem
Año:
2022
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza