Sex-specific and dose-response relationships of urinary cobalt and molybdenum levels with glucose levels and insulin resistance in U.S. adults.
J Environ Sci (China)
; 124: 42-49, 2023 Feb.
Article
en En
| MEDLINE
| ID: mdl-36182150
ABSTRACT
Growing studies have linked metal exposure to diabetes risk. However, these studies had inconsistent results. We used a multiple linear regression model to investigate the sex-specific and dose-response associations between urinary metals (cobalt (Co) and molybdenum (Mo)) and diabetes-related indicators (fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homeostasis model assessment for insulin resistance (HOMA-IR), and insulin) in a cross-sectional study based on the United States National Health and Nutrition Examination Survey. The urinary metal concentrations of 1423 eligible individuals were stratified on the basis of the quartile distribution. Our results showed that the urinary Co level in males at the fourth quartile (Q4) was strongly correlated with increased FPG (ß = 0.61, 95% CI 0.17-1.04), HbA1c (ß = 0.31, 95% CI 0.09-0.54), insulin (ß = 8.18, 95% CI 2.84-13.52), and HOMA-IR (ß = 3.42, 95% CI 1.40-5.44) when compared with first quartile (Q1). High urinary Mo levels (Q4 vs. Q1) were associated with elevated FPG (ß = 0.46, 95% CI 0.17-0.75) and HbA1c (ß = 0.27, 95% CI 0.11-0.42) in the overall population. Positive linear dose-response associations were observed between urinary Co and insulin (Pnonlinear = 0.513) and HOMA-IR (Pnonlinear = 0.736) in males, as well as a positive linear dose-response relationship between urinary Mo and FPG (Pnonlinear = 0.826) and HbA1c (Pnonlinear = 0.376) in the overall population. Significant sex-specific and dose-response relationships were observed between urinary metals (Co and Mo) and diabetes-related indicators, and the potential mechanisms should be further investigated.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Diabetes Mellitus
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Environ Sci (China)
Asunto de la revista:
SAUDE AMBIENTAL
Año:
2023
Tipo del documento:
Article
País de afiliación:
China