CD-SN38, CNDs conjugate with SN38; CDK7, cyclin-dependent kinase 7; CNDs, carbon nanodots; COLIαI, collagen type I alpha 1 chain; CPT11, camptotecin 11; CRC, colorectal cancer; Carbon dots; Cell cycle; Colorectal cancer therapy; Drug delivery; ECM, Extracellular Matrix; Extracellular matrix; FBS, fetal bovine serum; FCS, fetal calf serum; HT29, CRC cell line; HciGEnC, conditionally immortalized human glomerular endothelial cells; HciPodo, conditionally immortalized human podocytes; IF, immunofluorescence; Ki-67, antigen Ki-67; LD50, 50% lethal dose; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide; PBS, phosphate buffer saline; RPL4, Ribosomal Protein L4; RT, room temperature; SD, standard deviation; SN38; SN38, 7-etil-10-idrossi-camptotecina; TGFß1, transforming growth factor beta1; TME, Tumor Micro Environment; TNFα, tumor necrosis factor alpha; o.n., overnight