From signal transduction to protein toxins-a narrative review about milestones on the research route of C. difficile toxins.
Naunyn Schmiedebergs Arch Pharmacol
; 396(2): 173-190, 2023 02.
Article
en En
| MEDLINE
| ID: mdl-36203094
ABSTRACT
Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. difficile toxin research are presented with the focus on toxin B (TcdB), covering toxin structure, receptor binding, toxin up-take and refolding, the intracellular actions of TcdB, and the treatment of C. difficile infection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxinas Bacterianas
/
Clostridioides difficile
Idioma:
En
Revista:
Naunyn Schmiedebergs Arch Pharmacol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania