Diterpenoid DGA induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of STAT3 in glioma cells.

Kong, Tingting; He, Zhenxue; Wang, Shuying; Jiang, Chunxin; Zhu, Fei; Gao, Jingjing; Li, Liu; Wang, Yanping; Xie, Qing; Li, Yunsen

Kong, Tingting; He, Zhenxue; Wang, Shuying; Jiang, Chunxin; Zhu, Fei; Gao, Jingjing; Li, Liu; Wang, Yanping; Xie, Qing; Li, Yunsen.

Afiliación

Kong T; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
He Z; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Wang S; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Jiang C; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Zhu F; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Gao J; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Li L; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Wang Y; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Xie Q; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. Electronic address: qjie@suda.edu.cn.
Li Y; Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. Electronic address: yunsenli@suda.edu.cn.

Biochem Pharmacol ; 205: 115254, 2022 11.

Article en En | MEDLINE | ID: mdl-36210604

Asunto(s)

Neoplasias Encefálicas; Diterpenos; Glioma; Ratones; Animales; Humanos; Estrés del Retículo Endoplásmico; Proteína X Asociada a bcl-2/metabolismo; Ratones Desnudos; Glicoesfingolípidos/farmacología; Glicoesfingolípidos/uso terapéutico; Factor de Transcripción Activador 4/genética; Factor de Transcripción Activador 4/metabolismo; Factor de Transcripción CHOP/genética; Factor de Transcripción CHOP/metabolismo; Apoptosis; Glioma/patología; Diterpenos/farmacología; Diterpenos/uso terapéutico; Neoplasias Encefálicas/tratamiento farmacológico; Ceramidas/uso terapéutico; Factor de Transcripción STAT3/metabolismo

Palabras clave

Ceramide synthase; Endoplasmic reticulum stress; Glioma; Glycosphingolipid; STAT3

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Diterpenos / Glioma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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