C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect.

Fu, Ru-Huei; Tsai, Chia-Wen; Chiu, Shao-Chih; Liu, Shih-Ping; Chiang, Yu-Ting; Kuo, Yun-Hua; Shyu, Woei-Cherng; Lin, Shinn-Zong

Fu, Ru-Huei; Tsai, Chia-Wen; Chiu, Shao-Chih; Liu, Shih-Ping; Chiang, Yu-Ting; Kuo, Yun-Hua; Shyu, Woei-Cherng; Lin, Shinn-Zong.

Afiliación

Fu RH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Tsai CW; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Chiu SC; Department of Nutrition, China Medical University, Taichung 40402, Taiwan.
Liu SP; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Chiang YT; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Kuo YH; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Shyu WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Lin SZ; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.

Cells ; 11(19)2022 10 05.

Article en En | MEDLINE | ID: mdl-36231090

Asunto(s)

Esclerosis Amiotrófica Lateral; Esclerosis Amiotrófica Lateral/metabolismo; Animales; Arginina; Proteína C9orf72/genética; Proteínas Portadoras; Complemento C1/metabolismo; Dipéptidos/metabolismo; Dipéptidos/farmacología; Glucósidos; Humanos; Inflamasomas/metabolismo; Ratones; Microglía/metabolismo; Proteínas Mitocondriales/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Fenilpropionatos; Prolina; Proteínas/metabolismo

Palabras clave

C9orf72; HMC3 microglia cell; NLRP3 inflammasome; amyotrophic lateral sclerosis (ALS); complement component 1 q subcomponent-binding protein (C1QBP); mouse motor neuron NSC34 cell; proline-arginine dipeptide repeat protein (PR-DPR); syringin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cells Año: 2022 Tipo del documento: Article País de afiliación: Taiwán

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