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The Influence of the Severity of Early Chronic Kidney Disease on Oxidative Stress in Patients with and without Type 2 Diabetes Mellitus.
Andrade-Sierra, Jorge; Pazarín-Villaseñor, Leonardo; Yanowsky-Escatell, Francisco Gerardo; Díaz-de la Cruz, Elodia Nataly; García-Sánchez, Andrés; Cardona-Muñoz, Ernesto Germán; Munguía-Galaviz, Francisco Javier; de Alba-Razo, Alejandra; Miranda-Díaz, Alejandra Guillermina.
Afiliación
  • Andrade-Sierra J; Nephrology Service, Department of Internal Medicine, Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Guadalajara 44340, Jalisco, Mexico.
  • Pazarín-Villaseñor L; Nephrology Service, Department of Internal Medicine, Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Guadalajara 44340, Jalisco, Mexico.
  • Yanowsky-Escatell FG; Specialty in Nephrology, Regional General Hospital No. 46 IMSS, Guadalajara 44220, Jalisco, Mexico.
  • Díaz-de la Cruz EN; Nephrology Service, Department of Internal Medicine, Civil Hospital of Guadalajara "Dr Juan I. Menchaca", Guadalajara 44340, Jalisco, Mexico.
  • García-Sánchez A; Department of Health Sciences-Illness as an Individual Process, University Center of Tonalá, Tonala 44430, Jalisco, Mexico.
  • Cardona-Muñoz EG; Department of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Munguía-Galaviz FJ; Department of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • de Alba-Razo A; Department of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Miranda-Díaz AG; Department of Physiology, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Int J Mol Sci ; 23(19)2022 Sep 23.
Article en En | MEDLINE | ID: mdl-36232497
ABSTRACT
Early Chronic Kidney Disease (CKD) is a condition that tends to progress to End-Stage Kidney Disease (ESKD). Early diagnosis of kidney disease in the early stages can reduce complications. Alterations in renal function represent a complication of diabetes mellitus (DM). The mechanisms underlying the progression of CKD in diabetes could be associated with oxidative and inflammatory processes. This study aimed to evaluate the state of inflammation and oxidative stress (OS) on the progression of CKD in the early stages in patients with and without type 2 diabetes mellitus (T2DM). An analytical cross-sectional study was carried out in patients with CKD in early stages (1, 2, 3) with and without T2DM. The ELISA method determined the expression of pro-inflammatory cytokines IL-6 and TNF-α as well as lipoperoxides (LPO), nitric oxide (NO), and superoxide dismutase activity (SOD). Colorimetric methods determined glutathione peroxidase (GPx) and total antioxidant capacity (TAC). Patients with CKD and T2DM had significantly decreased antioxidant defenses for SOD (p < 0.01), GPx (p < 0.01), and TAC (p < 0.01) compared to patients without T2DM. Consequently, patients with T2DM had higher concentrations of oxidant markers, NO (p < 0.01), inflammation markers, IL-6 (p < 0.01), and TNF-α than patients without T2DM. CKD stages were not related to oxidative, antioxidant, and inflammatory marker outcomes in T2DM patients. Patients without T2DM presented an increase in SOD (p = 0.04) and a decrease in NO (p < 0.01) when the stage of CKD increased. In conclusion, patients with T2DM present higher levels of oxidative and inflammatory markers accompanied by a decrease in antioxidant defense. However, these oxidative status markers were associated with CKD stage progression in patients without T2DM. Thus, NO and SOD markers could help detect the early stages of CKD in patients who have not yet developed metabolic comorbidities such as T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Insuficiencia Renal Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: México

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Insuficiencia Renal Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: México