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Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats.
Dos Santos, Vinicius Ruan Neves; Motta, João Victor da Silva; Frazão, Deborah Ribeiro; Ferreira, Railson de Oliveira; Souza-Monteiro, Deiweson; Baia-da-Silva, Daiane Claydes; Mendes, Paulo Fernando Santos; Bittencourt, Leonardo Oliveira; de Moura, João Daniel Mendonça; Lameira, Osmar Alves; Balbinot, Gabriela de Souza; Collares, Fabrício Mezzomo; Rösing, Cassiano Kuchenbecker; Lima, Rafael Rodrigues.
Afiliación
  • Dos Santos VRN; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Motta JVDS; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Frazão DR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Ferreira RO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Souza-Monteiro D; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Baia-da-Silva DC; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Mendes PFS; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Bittencourt LO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • de Moura JDM; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
  • Lameira OA; Laboratory of Biotechnology, Embrapa Amazônia Oriental, Belém 66075-110, PA, Brazil.
  • Balbinot GS; Dental Materials Laboratory, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil.
  • Collares FM; Dental Materials Laboratory, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil.
  • Rösing CK; Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 90040-060, RS, Brazil.
  • Lima RR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Molecules ; 27(19)2022 Sep 23.
Article en En | MEDLINE | ID: mdl-36234793
Several studies have investigated the effects of natural products in the treatment of diseases. Traditional Amazonian populations commonly use copaiba due to its well-known anti-inflammatory, antibacterial, and healing properties. In this study, we aimed to investigate the effects of systemic administration of copaiba oleoresin (Copaifera reticulata Ducke) on ligature-induced periodontitis in rats. To do so, 21 adult rats were divided into three groups (n = 7 each): a control group, ligature-induced periodontitis group, and ligature-induced periodontitis group treated with copaiba oleoresin (200 mg/kg/day). The ligature remained from day 0 to 14, and the copaiba oleoresin was administered via oral gavage during the last seven days. On day 14, the animals were euthanized, and mandibles were collected for histopathological evaluation and microcomputed tomography analysis. Our data showed that the administration of copaiba considerably reduced the inflammatory profile. Moreover, copaiba oleoresin limited alveolar bone loss, increased trabecular thickness and bone-to-tissue volume ratio, and decreased the number of trabeculae compared with those of the untreated experimental periodontitis group. Our findings provide pioneering evidence that supports the potential of copaiba oleoresin in reducing periodontitis-induced alveolar bone damage in rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Pérdida de Hueso Alveolar / Fabaceae Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Pérdida de Hueso Alveolar / Fabaceae Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza