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PET Imaging of Self-Assembled 18 F-Labelled Pd2 L4 Metallacages for Anticancer Drug Delivery.
Cosialls, Raúl; Simó, Cristina; Borrós, Salvador; Gómez-Vallejo, Vanessa; Schmidt, Claudia; Llop, Jordi; Cuenca, Ana B; Casini, Angela.
Afiliación
  • Cosialls R; BISi-Bonds group, Dept. of Organic and Pharmaceutical Chemistry, Institut Químic de Sarrià, URL, Vía Augusta 390, 08017, Barcelona, Spain.
  • Simó C; Department of Organic and Inorganic Chemistry, Universidad del País Vasco (UPV/EHU), Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain.
  • Borrós S; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, San Sebastián, Gipuzkoa, Spain.
  • Gómez-Vallejo V; Department of Organic and Inorganic Chemistry, Universidad del País Vasco (UPV/EHU), Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain.
  • Schmidt C; Grup d'Enginyeria de Materials (GEMAT), Institut Químic de Sarrià,URL, Vía Augusta 390, 08017, Barcelona, Spain.
  • Llop J; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, San Sebastián, Gipuzkoa, Spain.
  • Cuenca AB; Chair of Medicinal and Bioinorganic chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748, Garching b. München, Germany.
  • Casini A; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014, San Sebastián, Gipuzkoa, Spain.
Chemistry ; 29(3): e202202604, 2023 Jan 12.
Article en En | MEDLINE | ID: mdl-36239701
ABSTRACT
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18 F-labelled [Pd2 L4 ]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cisplatino / Antineoplásicos Límite: Animals Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: España
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cisplatino / Antineoplásicos Límite: Animals Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: España