Recent and future perspectives on engineering interferons and other cytokines as therapeutics.
Trends Biochem Sci
; 48(3): 259-273, 2023 03.
Article
en En
| MEDLINE
| ID: mdl-36241490
ABSTRACT
As crucial mediators and regulators of our immune system, cytokines are involved in a broad range of biological processes and are implicated in various disease pathologies. The field of cytokine therapeutics has gained much momentum from the maturation of conventional protein engineering methodologies such as structure-based designs and/or directed evolution, which is further aided by the advent of in silico protein designs and characterization. Just within the past 5 years, there has been an explosion of proof-of-concept, preclinical, and clinical studies that utilize an armory of protein engineering methods to develop cytokine-based drugs. Here, we highlight the key engineering strategies undertaken by recent studies that aim to improve the pharmacodynamic and pharmacokinetic profile of interferons and other cytokines as therapeutics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Citocinas
/
Interferones
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos