A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy.
NPJ Precis Oncol
; 6(1): 72, 2022 Oct 14.
Article
en En
| MEDLINE
| ID: mdl-36241710
ABSTRACT
Personalized treatment approaches for patients with limited liver metastases from colorectal cancer are critically needed. By leveraging three large, independent cohorts of patients with colorectal liver metastases (n = 336), we found that a proliferative subtype associated with elevated CIN70 scores is linked to immune exclusion, increased metastatic proclivity, and inferior overall survival in colorectal liver metastases; however, high CIN70 scores generate a therapeutic vulnerability to DNA-damaging therapies leading to improved treatment responses. We propose CIN70 as a candidate biomarker to personalize systemic treatment options for patients with metastatic colorectal cancer. These findings are potentially broadly applicable to other human cancers.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
NPJ Precis Oncol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos