The effect of chronic hydergine treatment on the plasticity of synaptic junctions in the dentate gyrus of aged rats.
J Gerontol
; 42(5): 482-6, 1987 Sep.
Article
en En
| MEDLINE
| ID: mdl-3624806
ABSTRACT
The number of synapses (Nv), the surface density of contact zones (Sv) as well as the average size (S) of E-PTA stained synapses in the supragranular layer of the dentate gyrus from adult (12 months), old (30 month), and Hydergine-treated old (30 months) rats were measured by using quantitative morphometric techniques. In old animals, Nv and Sv were significantly reduced, whereas S was significantly increased as compared with the values in adult rats. Hydergine (Codergocrine mesylate) treatment of old animals (3 mg/Kg/day for 4 weeks) influenced these three parameters, differentially. The Sv in aged animals receiving Hydergine, relative to that in untreated old rats, was significantly increased; the number and size of synapses in the treated old rats were significantly higher and smaller, respectively, than that in old controls. We interpret the present findings to indicate a modulating effect of Hydergine on the morphological plasticity of synaptic junctions in the dentate gyrus of aged rats.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Dihidroergotoxina
/
Hipocampo
/
Plasticidad Neuronal
Límite:
Animals
Idioma:
En
Revista:
J Gerontol
Año:
1987
Tipo del documento:
Article