CRISPRi screening identifies CASP8AP2 as an essential viability factor in lung cancer controlling tumor cell death via the AP-1 pathway.

Myacheva, Ksenia; Walsh, Andrew; Riester, Marisa; Pelos, Giulia; Carl, Jane; Diederichs, Sven

Myacheva, Ksenia; Walsh, Andrew; Riester, Marisa; Pelos, Giulia; Carl, Jane; Diederichs, Sven.

Afiliación

Myacheva K; Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) - Partner Site Freiburg, Germany; Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg,
Walsh A; siTOOLs Biotech GmbH, Lochhamerstr. 29A, Planegg, Martinsried, Germany.
Riester M; Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) - Partner Site Freiburg, Germany.
Pelos G; Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) - Partner Site Freiburg, Germany.
Carl J; Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) - Partner Site Freiburg, Germany.
Diederichs S; Division of Cancer Research, Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) - Partner Site Freiburg, Germany; Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg,

Cancer Lett ; 552: 215958, 2023 01 01.

Article en En | MEDLINE | ID: mdl-36252816

Asunto(s)

Adenocarcinoma del Pulmón; Proteínas Reguladoras de la Apoptosis; Proteínas de Unión al Calcio; Neoplasias Pulmonares; Humanos; Adenocarcinoma del Pulmón/genética; Adenocarcinoma del Pulmón/metabolismo; Apoptosis/genética; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas; Detección Precoz del Cáncer; Pulmón/patología; Neoplasias Pulmonares/metabolismo; Factor de Transcripción AP-1/genética; Factor de Transcripción AP-1/metabolismo; Proteínas Reguladoras de la Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/metabolismo; Proteínas de Unión al Calcio/genética; Proteínas de Unión al Calcio/metabolismo

Palabras clave

Autophagy; CRISPR; Caspase; FLASH; Lung adenocarcinoma; NSCLC

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al Calcio / Proteínas Reguladoras de la Apoptosis / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Cancer Lett Año: 2023 Tipo del documento: Article Pais de publicación: Irlanda

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