A highly sensitive, easy-and-rapidly-fabricable microfluidic electrochemical cell with an enhanced three-dimensional electric field.
Anal Chim Acta
; 1232: 340488, 2022 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-36257751
ABSTRACT
An NP-µFEC is a reusable, novel microfluidic electrochemical cell with multiple non-planar interdigitated microelectrode arrays, minimal sample volume, and enhanced electric field penetration for highly sensitive electrochemical analysis. (i) The NP-µFEC features spatial 3-electrode architecture, and a small sample volume (â¼4 µL). (ii) Here, [Fe(CN)6]3-/4- redox couple are used as an electrochemical reporter. The effects on the electrochemical properties of NP-µFEC due to the change in the reference electrode (RE) and counter electrode (CE)'s position with respect to the working electrode (WE) position are analyzed. For NP-µFEC, the position of the RE with respect to the WE does not affect the CV, DPV electrochemical profiles. However, the spacing between the CE and WE plays a significant role. (iii) The enhanced three-dimensional electric field penetration in NP-µFEC is validated by finite element analysis simulation using COMSOL Multiphysics. (iv) Without electrode surface modifications, NP-µFEC shows a detection limit (DL) of â¼2.54 × 10-6 M for aqueous [Fe(CN)6]3-/4- probe. (v) The DL for Cu2+, Fe3+, and Hg2+ are 30.5±9.5 µg L-1, 181±58.5 µg L-1, and 12.4±1.95 µg L-1, respectively, which meets the US Environmental Protection Agency (EPA)'s water contamination level for Cu, Fe, and is close to that for Hg (EPA limits are 1300 µg L-1, 300 µg L-1, and 2 µg L-1, respectively). (vi) Further, using a pressure-sensitive adhesive layer to form the channel and create the NP-µFEC configuration simplifies the manufacturing process, making it cost-effective and allowing for rapid adoption in any research lab. NP-µFEC is used to detect heavy metal ions in water. This demonstrates that cost-effective, easy-to-fabricate NP-µFEC can be a new sensitive electrochemical platform.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metales Pesados
/
Mercurio
Tipo de estudio:
Diagnostic_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Anal Chim Acta
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos