Glutathione-depletion reinforced enzyme catalytic activity for photothermal assisted bacterial killing by hollow mesoporous CuO.
J Mater Chem B
; 10(43): 8883-8893, 2022 11 09.
Article
en En
| MEDLINE
| ID: mdl-36259979
ABSTRACT
The emergence and prevalence of drug-resistant bacteria caused by the overuse of antibiotics pose new challenges to the treatment of bacterial infections. In this work, hollow mesoporous CuO nanozymes (HM-CuO nanozymes) as excellent antibacterial agents were prepared by a template method. The synthesized HM-CuO nanozymes exhibit peroxidase-like catalytic activity, which can efficiently catalyze H2O2 to generate toxic reactive oxygen species (ROS), causing fatal damage to bacteria. Moreover, the hyperthermia of HM-CuO produced by photothermal therapy (PTT) not only effectively kills bacteria but also enhances the catalytic activity of nanozymes and produces more ROS. Moreover, the HM-CuO nanozymes have a glutathione (GSH)-depleting function to effectively consume GSH in bacteria and generate Cu(I) with higher catalytic effect, which can significantly improve the sterilization effect and produce a 100% inhibitory rate against E. coli and S. aureus. Overall, the HM-CuO nanozymes with strong peroxidase-like catalytic activity, excellent photothermal performance and GSH consumption ability offer a promising synergistic strategy for clinical bacterial infection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Bacterianas
/
Hipertermia Inducida
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Mater Chem B
Año:
2022
Tipo del documento:
Article