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Initial multicenter experience with ventricular assist devices in children and young adults with muscular dystrophy: An ACTION registry analysis.
Nandi, Deipanjan; Auerbach, Scott R; Bansal, Neha; Buchholz, Holger; Conway, Jennifer; Esteso, Paul; Kaufman, Beth D; Lal, Ashwin K; Law, Sabrina P; Lorts, Angela; May, Lindsay J; Mehegan, Mary; Mokshagundam, Deepa; Morales, David L S; O'Connor, Matthew J; Rosenthal, David N; Shezad, Muhammad F; Simpson, Kathleen E; Sutcliffe, David L; Vanderpluym, Christina; Wittlieb-Weber, Carol A; Zafar, Farhan; Cripe, Linda; Villa, Chet R.
Afiliación
  • Nandi D; Nationwide Children's Hospital, Columbus, Ohio. Electronic address: Deipanjan.Nandi@nationwidechildrens.org.
  • Auerbach SR; University of Colorado Denver, Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado.
  • Bansal N; Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.
  • Buchholz H; University of Alberta, Edmonton, Alberta, Canada.
  • Conway J; University of Alberta, Edmonton, Alberta, Canada.
  • Esteso P; Boston Children's Hospital, Boston, Massachusetts.
  • Kaufman BD; Lucile Packard Children's Hospital, Palo Alto, California.
  • Lal AK; Primary Children's Hospital, Salt Lake City, Utah.
  • Law SP; Morgan Stanley Children's Hospital of New York-Presbyterian, Columbia University Irving Medical Center, New York, New York.
  • Lorts A; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • May LJ; Primary Children's Hospital, Salt Lake City, Utah.
  • Mehegan M; St. Louis Children's Hospital, St Louis, Missouri.
  • Mokshagundam D; St. Louis Children's Hospital, St Louis, Missouri.
  • Morales DLS; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • O'Connor MJ; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Rosenthal DN; Lucile Packard Children's Hospital, Palo Alto, California.
  • Shezad MF; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Simpson KE; University of Colorado Denver, Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado.
  • Sutcliffe DL; Children's Mercy Hospital, Kansas City, Missouri.
  • Vanderpluym C; Boston Children's Hospital, Boston, Massachusetts.
  • Wittlieb-Weber CA; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Zafar F; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Cripe L; Nationwide Children's Hospital, Columbus, Ohio.
  • Villa CR; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
J Heart Lung Transplant ; 42(2): 246-254, 2023 02.
Article en En | MEDLINE | ID: mdl-36270923
ABSTRACT

PURPOSE:

Cardiac disease results in significant morbidity and mortality in patients with muscular dystrophy (MD). Single centers have reported their ventricular assist device (VAD) experience in specific MDs and in limited numbers. This study sought to describe the outcomes associated with VAD therapy in an unselected population across multiple centers.

METHODS:

We examined outcomes of patients with MD and dilated cardiomyopathy implanted with a VAD at Advanced Cardiac Therapies Improving Outcomes Network (ACTION) centers from 9/2012 to 9/2020.

RESULTS:

A total of 19 VADs were implanted in 18 patients across 12 sites. The majority of patients had dystrophinopathy (66%) and the median age at implant was 17.2 years (range 11.7-29.5). Eleven patients were non-ambulatory (61%) and 6 (33%) were on respiratory support pre-VAD. Five (28%) patients were implanted as a bridge to transplant, 4 of whom survived to transplant. Of 13 patients implanted as bridge to decision or destination therapy, 77% were alive at 1 year and 69% at 2 years. The overall frequencies of positive outcome (transplanted or alive on device) at 1 year and 2 years were 84% and 78%, respectively. Two patients suffered a stroke, 2 developed sepsis, 1 required tracheostomy, and 1 experienced severe right heart failure requiring right-sided VAD.

CONCLUSIONS:

This study demonstrates the potential utility of VAD therapies in patients with muscular dystrophy. Further research is needed to further improve outcomes and better determine which patients may benefit most from VAD therapy in terms of survival and quality of life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corazón Auxiliar / Insuficiencia Cardíaca / Distrofias Musculares Aspecto: Patient_preference Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corazón Auxiliar / Insuficiencia Cardíaca / Distrofias Musculares Aspecto: Patient_preference Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: J Heart Lung Transplant Asunto de la revista: CARDIOLOGIA / TRANSPLANTE Año: 2023 Tipo del documento: Article