Cyclodextrin metal-organic framework-based protein biocomposites.
Biomater Sci
; 10(23): 6749-6754, 2022 Nov 22.
Article
en En
| MEDLINE
| ID: mdl-36286095
ABSTRACT
Materials are needed to increase the stability and half-life of therapeutic proteins during delivery. These materials should be biocompatible and biodegradable. Here, we demonstrate that enzymes and immunoproteins can be encapsulated inside cyclodextrin based metal-organic frameworks using potassium as the metal node. The release profile can be controlled with the solubility of the cyclodextrin linker. The activity of the proteins after release is determined using catalytic and in vitro assays. The results show that cyclodextrin metal-organic framework-based protein biocomposites are a promising class of materials to deliver therapeutic proteins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ciclodextrinas
/
Estructuras Metalorgánicas
Idioma:
En
Revista:
Biomater Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos