Switchable Synthesis of 2-Methylene-3-aminoindolines and 2-Methyl-3-aminoindoles Using Calcium Carbide as a Solid Alkyne Source.
Org Lett
; 24(43): 8067-8071, 2022 Nov 04.
Article
en En
| MEDLINE
| ID: mdl-36286597
ABSTRACT
The one-pot three-component method for the switchable synthesis of 2-methylene-3-aminoindolines and 2-methyl-3-aminoindoles by reactions of N-(2-formylaryl)sulfonamides, secondary amines, and calcium carbide is described. This protocol has the salient features of the use of an inexpensive, abundant, and easy-to-handle solid alkyne source, avoiding the use of flammable and explosive gaseous acetylene as an original alkyne source. In addition, a wide scope of substrates, satisfactory yield, and simple workup procedure are also advantages of this method.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article