TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM<sub>2.5</sub> and Ultrafine Particles and Historically Showing Alzheimer and Parkinson's Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations.

Calderón-Garcidueñas, Lilian; Stommel, Elijah W; Lachmann, Ingolf; Waniek, Katharina; Chao, Chih-Kai; González-Maciel, Angélica; García-Rojas, Edgar; Torres-Jardón, Ricardo; Delgado-Chávez, Ricardo; Mukherjee, Partha S

TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM_2.5 and Ultrafine Particles and Historically Showing Alzheimer and Parkinson's Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations.

Calderón-Garcidueñas, Lilian; Stommel, Elijah W; Lachmann, Ingolf; Waniek, Katharina; Chao, Chih-Kai; González-Maciel, Angélica; García-Rojas, Edgar; Torres-Jardón, Ricardo; Delgado-Chávez, Ricardo; Mukherjee, Partha S.

Afiliación

Calderón-Garcidueñas L; College of Health, The University of Montana, Missoula, MT 59812, USA.
Stommel EW; Universidad del Valle de México, Mexico City 14370, Mexico.
Lachmann I; Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Waniek K; Roboscreen GmbH, 04129 Leipzig, Germany.
Chao CK; Roboscreen GmbH, 04129 Leipzig, Germany.
González-Maciel A; College of Health, The University of Montana, Missoula, MT 59812, USA.
García-Rojas E; Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
Torres-Jardón R; Universidad del Valle de México, Mexico City 14370, Mexico.
Delgado-Chávez R; Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Mukherjee PS; Independent Researcher, Mexico City 04310, Mexico.

Toxics ; 10(10)2022 Sep 24.

Article en En | MEDLINE | ID: mdl-36287840

Palabras clave

ALS; Alzheimer's; Aß142; Metropolitan Mexico City; PM2.5; Parkinson's; TDP-43; air pollution; cerebrospinal fluid; children; cisternal CSF; fronto-temporal dementia; hyperphosphorylated tau; nanoparticles; olfactory bulb granule cells; α synuclein

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies País/Región como asunto: Mexico Idioma: En Revista: Toxics Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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