A Cooling Conundrum: Is Therapeutic Hypothermia Safe in the Immunosuppressed?

Targeted temperature management (TTM) may increase the risk of infection, and immunosuppression is considered a relative contraindication despite the lack of robust evidence for this risk. We present a case of a 44-year-old immunosuppressed woman who suffered an out-of-hospital cardiac arrest, underwent TTM, and recovered neurological function without serious complications. The aim of this case is to navigate the challenging decision-making process regarding postcardiac arrest care in a patient on immunosuppressants.