Association of change in cardiovascular risk factors with incident dementia.
Alzheimers Dement
; 19(5): 1821-1831, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-36303296
ABSTRACT
INTRODUCTION:
We evaluated whether better cardiovascular health at midlife and improvement of cardiovascular health within midlife were associated with dementia risk.METHODS:
Two longitudinal population-based studies were used Atherosclerosis Risk in Communities (ARIC) (n = 11,460/visits at ages 54 and 60), and Age, Gene/Environment Susceptibility (AGES)-Reykjavik (n = 3907/visit at age 51). A cardiovascular health score (range 0-12/0-14, depending on diet availability) including six/seven items was calculated at each visit, with weight assigned to each item as poor (0), intermediate (1), or ideal (2). Cardiovascular health was defined as low (score 0-4/0-5), intermediate (5-7/6-9), or high (8-12/10-14). Incident dementia was ascertained through linkage to health records and with neuropsychological examinations.RESULTS:
Midlife high compared to low cardiovascular health (hazard ratios [HRs] for ARIC 0.60 [95% confidence interval 0.52, 0.69]); for AGES-Reykjavik 0.83 [0.66, 0.99] and improvement of cardiovascular health score within midlife (HR per one-point increase ARIC 0.94 [0.92, 0.96]) were associated with lower dementia risk.DISCUSSION:
Better cardiovascular health at midlife and improvement of cardiovascular health within midlife are associated with lower dementia risk. HIGHLIGHTS Cardiovascular health and dementia were studied in two large cohort studies. Better cardiovascular health at midlife relates to lower dementia risk. Improvement of cardiovascular health within midlife relates to lower dementia risk. Promotion of cardiovascular health at midlife can help to reduce dementia risk.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Demencia
/
Aterosclerosis
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
Alzheimers Dement
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos