Effect of Ivabradine on Left Ventricular Diastolic Function of Patients With Preserved Ejection Fractionã- Results of the IVA-PEF Study.
Circ Rep
; 4(10): 499-504, 2022 Oct 07.
Article
en En
| MEDLINE
| ID: mdl-36304432
ABSTRACT
Background:
The association between heart rate (HR) reductions caused by ivabradine and left ventricular (LV) diastolic function in heart failure with preserved ejection fraction (HFpEF) remains uncertain because of off-label use. Thus, the present study investigated the effect of HR reductions by ivabradine on LV diastolic function in HFpEF patients. MethodsâandâResults:
This study enrolled 16 HFpEF patients with HR ≥75 beats/min. After 3 months administration of ivabradine, no significant changes were observed in mitral inflow E and mitral e' annular velocities, B-type natriuretic peptide, or left atrial volume index, but there were significant improvements in global longitudinal strain.Conclusions:
Ivabradine did not improve LV diastolic function for HFpEF patients with HR ≥75 beats/min. Because this may be due to some study limitations, further studies should be conducted.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Circ Rep
Año:
2022
Tipo del documento:
Article