Co-encapsulation of retinoic acid, curcumin and resveratrol by spray-drying of alginic acid sodium-based emulsions and ethyl cellulose-based solutions: Impact on the co-delivery profiles.
Int J Biol Macromol
; 224: 1217-1227, 2023 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-36306910
ABSTRACT
Co-encapsulation of retinoic acid (RA), curcumin and/or resveratrol into microparticles composed by alginic acid sodium and the ethyl cellulose + polyethylene glycol (EC + PEG) blend was proposed for the protection and co-delivery of these bioactive compounds. The final aim is to take benefit of combined therapeutic potential related to these molecules and use loaded microparticles obtained by spray-drying to improve the treatment of acute promyelocytic leukemia (APL). Alginic acid sodium-based emulsions were characterized regarding rheological properties (i.e. viscosity), stability and droplet size distribution. Biopolymer- and synthetic polymer-based microparticles loaded with RA, RA + curcumin, RA + resveratrol and RA + curcumin + resveratrol were produced with a product yield between 10 and 35 %. The obtained microparticles exhibited a variable form, a morphology that varied between a slightly and high rough surface and a mean diameter that ranged from 2.97 ± 0.04 and 88 ± 3 µm. Encapsulation efficiency was significantly influenced by the encapsulating agent(s) used in the microparticles formulations. The bioactive compounds that were co-encapsulated showed a similar release profile.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Curcumina
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Portugal