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A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.
Vatanen, Tommi; Ang, Qi Yan; Siegwald, Léa; Sarker, Shafiqul Alam; Le Roy, Caroline I; Duboux, Stéphane; Delannoy-Bruno, Omar; Ngom-Bru, Catherine; Boulangé, Claire L; Strazar, Martin; Avila-Pacheco, Julian; Deik, Amy; Pierce, Kerry; Bullock, Kevin; Dennis, Courtney; Sultana, Shamima; Sayed, Sharika; Rahman, Mahbubar; Ahmed, Tahmeed; Modesto, Monica; Mattarelli, Paola; Clish, Clary B; Vlamakis, Hera; Plichta, Damian R; Sakwinska, Olga; Xavier, Ramnik J.
Afiliación
  • Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Liggins Institute, University of Auckland, New Zealand.
  • Ang QY; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Siegwald L; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland.
  • Sarker SA; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Le Roy CI; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland.
  • Duboux S; Nestlé Institute of Material Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland.
  • Delannoy-Bruno O; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland.
  • Ngom-Bru C; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland.
  • Boulangé CL; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland.
  • Strazar M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Avila-Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Deik A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Pierce K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bullock K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Dennis C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Sultana S; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Sayed S; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Rahman M; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Ahmed T; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Modesto M; Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 42, 40127 Bologna, Italy.
  • Mattarelli P; Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 42, 40127 Bologna, Italy.
  • Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Plichta DR; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
  • Sakwinska O; Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., 1000 Lausanne, Switzerland. Electronic address: olga.sakwinska@rdls.nestle.com.
  • Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA. Electronic address: rxavier@broadinstitute.org.
Cell ; 185(23): 4280-4297.e12, 2022 11 10.
Article en En | MEDLINE | ID: mdl-36323316
ABSTRACT
The gut microbiome has an important role in infant health and development. We characterized the fecal microbiome and metabolome of 222 young children in Dhaka, Bangladesh during the first two years of life. A distinct Bifidobacterium longum clade expanded with introduction of solid foods and harbored enzymes for utilizing both breast milk and solid food substrates. The clade was highly prevalent in Bangladesh, present globally (at lower prevalence), and correlated with many other gut taxa and metabolites, indicating an important role in gut ecology. We also found that the B. longum clades and associated metabolites were implicated in childhood diarrhea and early growth, including positive associations between growth measures and B. longum subsp. infantis, indolelactate and N-acetylglutamate. Our data demonstrate geographic, cultural, seasonal, and ecological heterogeneity that should be accounted for when identifying microbiome factors implicated in and potentially benefiting infant development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bifidobacterium longum Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant País/Región como asunto: Asia Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article País de afiliación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bifidobacterium longum Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant País/Región como asunto: Asia Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article País de afiliación: Nueva Zelanda