Where is bone science taking us?
Best Pract Res Clin Rheumatol
; 36(3): 101791, 2022 Sep.
Article
en En
| MEDLINE
| ID: mdl-36336607
ABSTRACT
Bone science has over the last decades unraveled many important pathways in bone and mineral metabolism and the interplay between genetic factors and the environment. Some of these discoveries have led to the development of pharmacological treatments of osteoporosis and rare bone diseases. Other scientific avenues have uncovered a role for the gut microbiome in regulating bone mass, which have led to investigations on the possible therapeutic role of probiotics in the prevention of osteoporosis. Huge advances have been made in identifying the genes that cause rare bone diseases, which in some cases have led to therapeutic interventions. Advances have also been made in understanding the genetic basis of the more common polygenic bone diseases, including osteoporosis and Paget's disease of bone (PDB). Polygenic profiles are used for establishing genetic risk scores aiming at early diagnosis and intervention, but also in Mendelian randomization (MR) studies to investigate both desired and undesired effects of targets for drug design.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteítis Deformante
/
Osteoporosis
/
Enfermedades Óseas
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Best Pract Res Clin Rheumatol
Asunto de la revista:
REUMATOLOGIA
Año:
2022
Tipo del documento:
Article